Corneal Biomechanics Assessment Using High Frequency Ultrasound B-Mode Imaging

Assessment of corneal biomechanics for pre- and post-refractive surgery is great clinical importance. Corneal affect vision quality human eye. Many factors such as, age, diseases refractive surgery. There a need non-invasive in-vivo measurement due to shape preserving as opposed ex-vivo measurements that destructs tissue. In this study, new approach assessing non-invasively using ultrasound estimation method with 100 KHz frame rate proposed. Three models in conjunction each other are used study the behavior tissue These three cornea FEM, scatterrer model transducer respectively. Nine different elastic moduli constructed achieve goal; 140KPa, 300KPa, 600KPa 800KPa 1MPa, 1.5MPa, 2MPa, 2.5MPa 3MPa pre-refractive Time-To-Peak (TTP) deformation, deformation amplitude (DA), ratio at 2 mm (DA mm) shear wave speed (SWS) estimated nine involved study. Results show TTP decreasing (6.9 msec. 140KPa 5.3 3MPa) while increasing modulus Also, DA (2 0.5 3MPa), well. However, shows decrease reflect difficulty deform uniformly higher moduli. Estimated SWS an average accuracy 98% theoretical SWS.